Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population
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چکیده
منابع مشابه
Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.
RATIONALE An asthma predisposition locus on chromosome 17q12-q21 has recently been replicated in different ethnic groups. OBJECTIVES To characterize the asthma and atopy phenotypes in early childhood that associate with the 17q12-21 locus. METHODS The single nucleotide polymorphism (SNP), rs7216389, was genotyped in 376 of 411 children from the Copenhagen Prospective Study on Asthma in Chil...
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Background: The 5, 10-methyleneterahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are two essential enzymes involved in folate metabolism. The relationship between genetic polymorphisms and congenital heart defects (CHDs) is inconsistent. Our aim was to investigate the association between two well-known polymorphisms of MTHFR and MTRR genes, C677T and A66G, respectively,...
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Methods Five tagSNPs covering FLG have been genotyped in 237 trios from the Saguenay-Lac-Saint-Jean population using a Sequenom panel. In addition, a genome-wide association study (GWAS) has also been done for the same trios in the large-scale GABRIEL project http://www. gabriel-fp6.org/. The polymorphisms (SNPs) included in FLG and FLG2 as well as those in the 3’ and 5’ UTR regions were extrac...
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BACKGROUND The meiotic program initiation pathway genes (CYP26B1, NANOS1 and STRA8) have been proposed to play key roles in spermatogenesis. OBJECTIVE To elucidate the exact role of the genetic variants of the meiosis initiation genes in spermatogenesis, we genotyped the potential functional genetic variants of CYP26B1, NANOS1 and STRA8 genes, and evaluated their effects on spermatogenesis in...
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Melatonin may have important immunostimulatory actions in allergic diseases, in addition to its well-known antioxidant and cytoprotective effects in several inflammatory conditions. The activation of the immune system leads to free radical production associated with decreased melatonin levels and depressed antioxidant enzyme activities in several inflammatory diseases. Many skin disorders, incl...
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ژورنال
عنوان ژورنال: Allergy, Asthma & Clinical Immunology
سال: 2019
ISSN: 1710-1492
DOI: 10.1186/s13223-019-0340-7